Past Project: Sirtuin Deacylation

Sirtuin deacylation mechanisms and conformational flexibility.

Part of my thesis titled “A Structural Approach to Protein Intrinsic Versatility – the Tale of Succinyllysine Reader GAS41 and Palmitoyllysine Eraser SIRT3”.

Publication

Wang Y, Fung YME, Zhang W, He B, Chung MWH, Jin J, Hu J, Lin H, Hao Q. Deacylation mechanism by SIRT2 revealed in the 1’-SH-2’-O-myristoyl intermediate structure. 2017. Cell Chemical Biology. 24(3):339-345. DOI: 10.1016/j.chembiol.2017.02.007.

To be updated.